Piper's Experience with GME

Piper Clyde

February 7, 2008 - March 28, 2023

GME is an emotional rollercoaster:
  • Misdiagnosis
  • What is wrong?
  • Is the seizure a relapse?
  • What are the side effects of the treatment?
  • When do we titer prednisone?
  • What supplements can we use?
We hope Piper's playful spirit lives on and her story helps those that are dealing with GME understand what is "normal" for the disease and what you may encounter during your GME battle.

Piper lived 6 years in remission. We are forever grateful for those 6 extra years with our precious girl. There is hope!
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This history was compiled from the journal we kept throughout Piper's GME journey.

13 April 2008

Piper Moved to Kentucky!

Having spent months saying, "I want a little dog to follow me around, hang out with me, play with me, and be my best friend," we were SO excited to pick up Piper from the airport in Cincannati, OH after she flew down from Buffalo, NY! 

This is Piper in her first picture on the first day in her forever home!

13 April 2008

2008-2016

A Happy Havanese!

Piper was an incredibly intelligent dog with a LOT of energy!

She loved playing puzzle games, soccer balls, her sisters (Tobie & Gracie), and her humans.

January 5, 2017

The First Signs Something Wasn't Quite Right

Piper was acting distant and not wanting to play her normal games at night. VERY unusual for Piper. She ALWAYS wanted to play her nightly treat games. 

We also noted that she was panting for what seemed like no apparant reason but she had a good appetite.

January 5, 2017

January 7, 2017

Increased Panting and Head Pressing

Piper started pressing her head on chairs and on her bed. She would head press multiple times a day. 

She was still withdrawn and not wanting to play her nightly treat games or wrestle with her sister. 

She also continued to pant for no apparent reason.  She'd be sleeping and wake up panting.

January 10, 2017

Hardwood Floors = Hot Lava

We have hardwood floors throughout our house with rugs.

In early January 2017, Piper started "carpet hopping" in the house.

She acted like the floor was hot lava and would jump from rug to rug.

Our vet said she had luxating patellas and recommended laser therapy to strengthen her knees.

January 10, 2017

January 17, 2017

Withdrawn and Head Positioning

In this poor quality video from January 17th, Piper is in the bathroom closet.

We had noticed when she was laying down, her "normal head posture" was having her head tilted backwards and reclined back.

At the time we knew it wasn't "normal" and there was something "off" but we had no idea what was going on.

January 20, 2017

Carpet hopping was getting worse

We tried socks with treads on the bottom.

We tried toe nail guards to help her not slip on the hardwood.

We even bought a bunch of carpeted stair treads and made paths throughout the house so she wouldn't have to walk on the hardwood.

You name it, we tried it; but the carpet hopping was not getting better.

At Piper's laser therapy visit, she was given pain medication to help provide some relief.

January 20, 2017

January 26, 2017

Laser Therapy on Her Knees Wasn't Helping

Over the next 3 weeks, Piper had 3 more laser therapy treatments on her knees (one a week). We also noticed she was:
  • More withdrawn
  • Stopped playing her nightly puzzle games
  • Panting more 
  • Rubbing her head more
Her favorite place to lay was in her "cave bed" or "kennel bed" where it was dark. 

When I could get her to lay on the couch with me, she would lay with her head elevated (like she is in the picture, below).

January 28, 2017

Loss of Confidence, Pacing, and General Discomfort

Over the next week instead of getting better, Piper became more withdrawn and started to refuse food.

We also noticed: 
  • She was panting a lot
  • Would move from bed to bed as she couldn't get comfortable
  • Lost her confidence about moving from point A to point B
  • Didn't want up on the furniture because she wasn't confident about jumping down
  • Started over-exagerating jumping over the threshold to the door when she came in from the outside
  • Started having issues jumping up the 2 steps in the house.

January 28, 2017

February 7, 2017

Can't Find the Door To Come Back Inside

On one of the house cameras, we watched a heartbreaking video of Piper trying to get into the house from the wrong side of the house. 

She was very disoriented and unable to find her way to the correct side of the house where the door is located. 

Her sister, Tobie tried to help her and get her to come around to the other side of the house. 

We assumed it was something wrong visually.  We had also noticed when we gave her a treat that she accidentally bit down on fingers instead of the treat like she couldn't see it.

February 14, 2017

Urinary Tract Infection

The night of Feburary 13, 2017, Piper and I were sitting on the loveseat watching TV.

She suddenly jumped up and leaped into my lap where I discovered she was wet as she had urinary incontinence.

I called the next morning and was able to get Piper into an appointment late that afternoon so at 5:10 pm on Feburary 14, we were at the vet.

Piper was diagnosed with a urinary tract infection and given antibiotics.

February 14, 2017

February 14, 2017

All Hell Broke Loose

It was almost 11 pm on Tuesday night.

Piper was sleeping in her wooden kennel where she had been going a lot.

She came out with a wide stance, reared up on her 2 back legs, then fell over backwards hitting her head on the floor. 

I jumped from the couch and dove across the room, getting my hands under her before she fell over backwards the second time.

I just tried to keep her from hurting herself as she had a grand mal seizure.

I put one hand under her head to it wouldn't hit the floor and just tried to keep her from flopping around a lot throughout the seizure while I told her how much we loved her and that we would find out what was going on.

February 15, 2017

Dr Visit Followed by Emergency Room Admission

The next morning we called our veterinarian as soon as they opened. 

They did bloodwork and x-rays on her head and neck.  They said they felt it was "vestibular due to stumbling, head tilt, etc." and recommended we take her to the emergency room an hour away because a canine neurologist was on staff and that would be the fastest way to get her under her care.

We got in the car and immediately drove the hour to Louisville, KY from Lexington. 

When we got there, the emergency room Dr who did her exam said he thought Piper had Sudden Acquired Retinal Degeneration or (SARDS).

We were in complete shock. There was no way she was suddenly blind. We knew she could see but she definitely had issues with depth perception.

The neurologist was out of town and not due back until the next day but they recommended they put Piper on anti-seizure medication and watch her overnight. The neurologist would do a full neuro exam the next day.

We agreed.

February 15, 2017

February 16, 2017

First Neurology Exam and a Bad Decision

The neurologist completed her exam and said she suspected GME or Granulomatous Meningoencephalitis but Piper needed an MRI with analysis of the cerebral spinal fluid to verify. 

We were terrified to put Piper through an MRI.

We were hoping the Levetiracetam (Keppra) they put her on would stop the seizures so we opted to try the medication to see how she did on that and not do the MRI at that time. 

Lesson Learned: If your canine neurologist says you need to have an MRI done, get it done as soon as possible. GME is not responsive to anti-seizure medication.

When we got home from the neurology appointment, we hit Google and found mostly older articles that were very difficult to read. None of the articles talked about the typical treatment plan, offered hope, or helped us understand that time was truly of the essence when treating a GME animal.

February 17, 2017

Typical Piper GME Seizure

Most of Piper's seizures were like this ... very subtle and not obvious that it was a seizure. 

Then, she would have an occassional "BIG" full body, loss of continence, seizure. 

February 17, 2017

February 20, 2017

Piper Needs an MRI & Analysis of the Cerebrospinal Fluid

The first few days on Keppra we were very hopeful as Piper didn't have a seizure.

Our hope was short-lived. On day 3 Piper had another massive seizure with urinary incontenance. We called the veterinary hospital and scheduled the MRI for the next week (the earliest she could get in for it).

We set up a dog playpen with blankets, her bed, and potty pads. We also noticed a fairly rapid increase in symptoms: 

  • More dazed and disoriented
  • Doing a LOT of face rubbing and head pressing. She would mash her face into blankets and rub her head on the side of her playpen
  • Drinking more water
  • We gave her a bone to chew and she acted like she had no idea what to do with it
  • Her right eye became droopy and the was not aligned correctly - she would look at you but her right eye was looking a different direction
  • She would lay down and then jerk herself up with her head tilted back in extension
  • Acted nauseated 
  • More panting and slobbery 

Over the week, the seizures were getting more frequent and more intense.

In this video, you can see the face pressing on the playpen (blankets removed for washing) and how Piper reacted when she realized she was on the hardwood floor.

Piper Diagnosed with GME

Piper had the MRI with lumbar puncture (spinal tap).

Following the MRI, we met with the neurologist and looked at the MRI. 

Piper had granulomatous meningoencephalomyelitis (GME). The dye was taken up in multiple regions of her brain so it was disseminated or multifocal.

We wouldn't know if the cause was from her immune system or an infection until we got the results of the cerebral spinal fluid back to look for bacteria/virus presence.
  • She was eating and drinking
  • Her depth perception was in rapid decline
  • She was tracking "ok" but was rapidly losing her eyesight 
Time to treatment was vital to having a good prognosis.
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March 14, 2017

Start of Treatment in the Hospital

The neurologist explained that treatment needed to start immediately as time was crucial. She went from the MRI facility back to the hospital were she was put on intravenous broad spectrum antibiotic, high dose dexamethasone (steroids), and a higer dose Keppra.

We gave Piper lots of kisses and left her in Dr. Ruehlmann's care for her overnight hospital stay.

March 14, 2017

March 16, 2017

Piper Got to Come Home From the Hospital

Early afternoon we got to pick Piper up and bring her home. 

She felt horrible but she was alert in the hour drive home in the car. She was rubbing her eat a lot in her car seat.

When we got her home, she did pretty good on her 8 pm meds: 
  • Clavamox 1 - 62.5 mg tablet

At 11 pm we gave her: 
  • A 1/2 tablet of Zophran 
  • 0.8 mL of Levetiracetam (100 mg/mL)  
  • 1 tablet of Omeprazole (5 mg tablets) 

March 17, 2017

Back to the Hospital We Go

Our first day of giving Piper all of her medicine didn't go well. 

She got up to potty at 5 am (understandable with all the IV fluids she got at the hospital). She went back to sleep after we gave her 1/2 a Pepsid. 

At 8 am she got

  • 1 1/4 tablet of a 5 mg Presnisone
  • 1/4 tablet of Metronidazole
  • 1 tablet of Clavamox (62.5 mg tablets)
  • 1/2 tablet of Zofran 
  • 0.8 mL of Levetiracetam (100 mg/mL)  

Piper got sick multiple times after breakfast and refused food at lunch. 

The hospital recommended we try to feed her more frequent but smaller meals. She was refusing all food.

At 4 pm we were able to get 1/2 a tablet of Zofran in her. 

She had diarrhea that afternoon.

She ate a small supper but then got really sick and was going downhill fast. She wasn't able to hold down medications and we were hovering our hand over the panic button.

We called the hospital who recommended we take her in so they can put her on IV meds. 

We drove the hour to the hospital and admitted her.

March 17, 2017

March 18, 2017

Hospitalization Stay

We talked to Piper's neurologist on Saturday who said they were able to get her GI effects from the steroids under control and she was improving neurologically. 

Recommended she stay in the hospital until she is able to be transitioned to oral meds.

March 20, 2017

Results from the Spinal Fluid & First Chemotherapy Treatment

On Monday, we got the results from the PCR (polymerase chain reaction) studies from the spinal fluid. 

There was no presence of fungal, protozoal, bacterial, or viral in her spinal fluid which confirmed the diagnosis of immune mediated granulomatous meningoencephalomyelitis (GME).

We were given multiple treatment options. 

Option 1: 

Cytarabine dosed every 4 weeks for 6 months. The infusion would need to run for 4-6 hours per session. It has a good history of crossing the blood/brain barrier for treatment. 

Continue with high dose prednisone, Keppra, the antibiotics (Piper had developed a UTI), and all of the nausea/GI meds. 

Option 2: 
Lomustine with high dose prednisone, Keppra, the antibiotics (Piper had developed a UTI), and all of the nausea/GI meds. 

Has a good results but Option #1 has a more potent effect on the bone marrow with white blood cells. 

Option 3: 
Cyclosporine with high dose prednisone, Keppra, the antibiotics (Piper had developed a UTI), and all of the nausea/GI meds. 

Not as effecive through oral medication and has only been in treatment plan for 3-5 years. Side effect is diarrhea.

Option 4: 
Azathioprine with high dose prednisone, Keppra, the antibiotics (Piper had developed a UTI), and all of the nausea/GI meds. 

Not as effecive through oral medication and has only been in treatment plan for 3-5 years. Side effect is diarrhea. 

We chose to go with Option 1 as it has had the highest success rate in experience by the hospital at achieving remission. It is a rough treatment - chemotherapy. 

Piper would get her first treatment that same day and then get to come home if it went well!

March 20, 2017

March 21, 2017

A Fragile and Terrifying Return Home

Piper did a great job handling the chemotherapy.  A little diarrhea but the meds were helping with the GI upset.

Melissa picked Piper up from the hospital as I was in DC for a required work meeting. She had some nausea in the car ride on the way home but she was coming home!!! 

I will never forget Melissa's description of how incredibly fragile Piper was. She was terrified to leave her alone. Terrified to even take the time to take a shower. 

The medicine regime was intense. We developed a Google Sheet to track all of her medication which I've generalized to make it usable for others.

Upon Waking Up: 
  • 1/2 tablet of Pepsid (10 mg)
8 AM:
  • 1 1/4 tablet of Prednisone (5 mg tablets)
  • 1 tablet of Metronidazole (50 mg tablets)
  • 1/2 tablet of Clavamox (62.5 mg tablets)
  • 1/2 tablet of Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  
4 PM: 
  • 1/2 tablet Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  
8 PM:
  • 1 1/4 tablet of Prednisone (5 mg tablets)
  • 1 tablet of Metronidazole (50 mg tablets)
  • 1/2 tablet of Clavamox (62.5 mg tablets)
11 PM: 
  • 1/2 tablet Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  
  • 1 tablet Omeprazole (5 mg tablets) 
Piper stayed in the playpen in the living room filled with blankets and her bed. She had a pee A LOT (every hour day and night). 

She was still very wobbly, restless, and pacing. 

Her sister, Tobie demanded to be let into the playpen to sleep near Piper. When the door was zipped shut, Tobie would lay next to the playpen.

We were all so happy to have our girl home!

March 23, 2017

No Sleep for the Tired

A rough day. We think the prednisone is making her restless and kept her up all night so she didn't sleep a wink. She is lethargic and acting off. 

Eyes were dull. Stayed in the playpen most of the day. She had some trouble going in/out the pet door. 

Feeling very skinny.

March 23, 2017

March 25, 2017

One Medicine Off the Regime!

We got to remove the Metronidazole from Piper's medicines! 

We noted to the Dr that she felt very scrawny. She said it was "normal" and would likely get worse before it got better as the high dose prednisone causes muscle waste. 

March 29, 2017

Clavamox Completed!

We get to remove another medicine! 

Done with the Clavamox!

March 29, 2017

April 1, 2017

We'll Take Stable!

Piper was generally stable. She was acting more like herself than she had since this started. 

She wasn't as active as before but her balance was a little better and we didn't notice as many "zoning out episodes". 

Was able to remove Zofran.

April 2, 2017

Too Much Activity = Big Neurological Effects

We pretty quickly realized Piper's threshold for activity was VERY low. 

An episode of barking because someone was at the front door or just too much activity.

Piper felt horrible for days after having a big barking episode. While she had been making progress and not over-exaggerating jumping over door thresholds and was walking on the hardwood floors, after the barking episode, the hardwood floors were hot lava again and she would jump WAY over a level door threshold.

April 2, 2017

April 5, 2017

Thunderstorms and Headaches

We had increased Piper's Keppra and she went to get her soccer ball for the first time in weeks!  Later that same day she even chewed on a bone. 

That night we had a bad thunderstorm. We are guessing the change in barometric pressure caused a massive headache/migraine. She was nauseated, unstable footing, and downright cranky. 

By the next evening, she was feeling a bit better and even stole her sister's bone.

April 9, 2017

The 1st Reduction of Prednisone

Upon Waking Up:

  • 1/2 tablet of Pepsid (10 mg)

8 AM:

  • 1 1/4 tablet of Prednisone (5 mg tablets)
  • 1 tablet of Metronidazole (50 mg tablets)
  • 1/2 tablet of Clavamox (62.5 mg tablets)
  • 1/2 tablet of Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  

4 PM:

  • 1/2 tablet Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  

11 PM:

  • 1/2 tablet Zofran
  • 0.8 mL of Levetiracetam (100 mg/mL)  
  • 1 tablet Omeprazole (5 mg tablets) 

April 9, 2017

April 9, 2017

Best Case Scenario Achieved

Since the reduction in prednisone and increase in Keppra, Piper hasn't had a massive set-back so we are very hopeful that we are making progress in reducing the inflammation in her brain!

The low dose prednisone IS controlling the inflammation! 

Piper is playing more with toys, chewing bones, and engaging some with her puzzle games. 

She is obsessively licking MY arms and legs but it seems to calm her down so lick away. 

If she does bark a lot or over-do it in activity she continues to have a set-back but by the next day she seems to be back to her happy self.

April 28, 2017

Destroyed a Soccer Ball!

Late April Piper was starting to act more like herself!

She destroyed a soccer ball for the first time in 2017! 

what to expect from gme


April 28, 2017

May 17, 2017

3 of 6 Chemotherapy Sessions Done!

Our little GME warrior has made it to the 1/2 way point of chemotherapy! 

gme treatment dog

She continued to have set-backs from high activity but the next morning, she would bounce back.

We were able to reduce her prednisone again! 

She was now taking

  • Pepsid first thing in the morning 
  • 1 1/4 tablets of prednisone at 8 am
  • 1 tablet of Keppra 3x/day (8 am, 4 pm and 11 pm) 

July 3, 2017

Ride In Style!

Piper seemed frustrated getting easily tired and having set-backs neurologically so we got her a stroller!  She can take her sister on a walk and not get too tired! 


Piper also got to reduce her prednisone AGAIN!  

She kept taking Pepsid and Keppra but was down to 3/4 of a tablet at 8 am daily.

July 3, 2017

July 12, 2017

Almost to the Finish Line!

Piper continued to do great. 

She was eating, playing, and acting like her normal self! 

Still taking prednisone and Keppra. 

August 7, 2017

CHEMO DONE!!!!

On August 7, 2017 we celebrated Piper COMPLETING chemotherapy!!!! 

Here she is with her amazing neurologist, Dr. Debbie Ruehlmann, DVM, Diplomate ACVIM (Neurology).

August 7, 2017

September - November 2017

Steady As She Goes

Piper welcomed a new sister into the household and she continued to do really well after completing chemotherapy. 



In Ocbober 2017, she was able to take prednisone every other day!!

Mission Accomplished!

At the end of 2017, Piper was able to completely transition off prednisone! 

We tried multiple times to reduce her Keppra in 2018 and again in 2019 but each time resulted in neurological issues or seizures.

Since Keppra is a relatively safe anti-seizure medication, we continued it at high dose.

We are so grateful for the team at Metropolitan Veterinary Hospital and Dr. Ruehlmann for saving Piper's life. We have no doubt that without them/her she'd not be here today. 

We also think it is important to note that GME changed Piper. 

She was still her happy super smart self who loved to play puzzle games, would act like a clown, and she meant the world to us, but she was not the same after treatment as she was before. 

We think this is in part to the advanced inflammation in her brain by the time she started treatment. The delays in mis-diagnosis, delays in not understanding the seriousness of GME and how important speed was in stopping the inflammation, etc. did cause permanent damage in Piper's brain. 

She had a single focus on activities and no longer wrestled with her sister like she did before. 

Too much activity would give her headaches and she'd not feel well until the next morning.  

She was less patient with puzzle toys. 

She had decreased vision and depth perception. She never did the 2 steps in the house again and her depth perception was always off.
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February, 2022

Balance Issues?

We started to notice subtle things with Piper. 

She would be tilted when standing or just not completely balanced but was acting normal.  She was very active, happy, eating, etc.

February, 2022

July 2, 2022

2 Days In A Row ~ Grand Mal Seizures

Piper had a much more intense seizure with foaming at the mouth. The seizure lasted less than a minute. 

The next day (July 3, 2022), Piper had another severe seizure that lasted over 2 minutes (foaming at mouth), pronation to the left, shaking, etc.

July 2nd Seizure

Piper was absolutely terrified (and so were we).

After talking to her neurologist, we increased Keppra for 24 hours (a 375 mg dose every 4 hours (11 am, 3 pm, 11 pm, 3 am, 7 am and 11 am) to see if we could stop the seizures from escalating. It did seem to work. 

July 8, 2022

Neurology Exam

This is Piper giving me the stink eye .... she knows we're at the vet and she's not happy but we need to see if the neurologist thinks the GME is back. 



Neurology Exam Results:

  • Piper is very engaged, incredibly intelligent (we knew that), and very active
  • No new deficits were noted
  • There were no clear signs that GME was back but it could be very early stage
  • The only way to know if the GME is back is to do an MRI with lumbar puncture
  • Primary concern is Piper's medication (Keppra) is no longer able to control the seizures and Piper is at the maximum dose for her size/weight
  • Piper's heart, kidneys, etc. all look good
  • Piper's gallbladder is still "sludgy" but hasn't changed significantly
  • Still has slightly elevated liver enzymes. They had gone down but were starting to come back up


Treatment Options: 

  1. Get the MRI with lumbar puncture to see if GME is back.
  2. Change her seizure medication. Piper was on the max dose of Keppra for her weight/size but we could change her to another seizure medication.
  3. Add homeopathy to see if it could, in combination with Keppra, help to control the seizures.


Our Decision: 
We chose to not get the MRI given Piper's age (14).

She was experiencing dementia (notably at night) but was still very active, engaged, and happy. Having the MRI wasn't going to change our course of action - to minimize the trauma to Piper while controlling the seizures.

Given how safe Keppra is compared to other anti-seizure medications, we chose to try homeopathy.

July 8, 2022

July 20, 2022: Homeopathy Is Amazing!

We did a Zoom consult with Brenda Tobin, DiHom, D.Vet.Hom, Cert. C.N. with Wellness Matters.

It was a 2+ hour consult where we watched the video of Piper's last seizure and answered a LOT of questions. Here are some of them: 
  • What did Piper do before the seizure? 
  • What did Piper do after the seizure? 
  • She was foaming at the mouth. What color was it? Did it have an odor? 
  • What was the weather? 
  • What time did she have the seizure? 
  • How did she act after the seizure? Did she sleep? Was she out of it? Was she normal? 
  • How long did it take her to be back to herself? 
  • Has she been rubbing her head or ears?
  • Any tummy issues? 
  • What does she eat?
  • What treats does she eat? 
  • What is her vaccine history? 
  • What medication is she on?
  • What supplements does she take?
  • Does she prefer to be warm or cold? 
  • Does she prefer warm or cold water? 
  • Does she gulp water or drink slowly?
  • Any issues with balance?
At the end of the virtual (Zoom) appointment, Brenda told us which remedy to purchase from Hahnemann Labs.

NOTE: We will not disclose the remedy we used as each remedy is VERY specific to the animal. You MUST have an expert identify the remedy based upon the specific needs of your pet.

We started with 2 pellets of the remedy in the morning and 2 pellets in the evening (15 minutes before and after food/treats).

IT WORKED!  The seizures stopped!!!!

This is one of hundreds of videos of we have with Piper
playing her nightly game of "flinch" ~ feeling GOOD!

September 13, 2022

The Power of Homeopathic Remedies!

Piper was doing so well on homeopathy that the decision was made to reduce the pellets to 2/day. 

It was scary to go down from 4 pellets to 2 a day but Piper did fantastic!  No seizures!

September 13, 2022

December 28, 2022

Dementia

Piper started exhibiting signs of dementia. We gave her Real Mushrooms Lion's Mane and RealClarity (Lion's Mane, Ashwagandha, Rhodiola and Bacopa) which seemed to help with the restlesness but her separation anxiety was very bad
  • Restless and unsettled at night; pacing at night
  • Extreme separation anxiety 
The last time Piper went outside to potty without supervision, I was outside but on the other side of the house. When she didn't come back in a normal amount of time, I went to look for her and found she had fallen into the crawl space well. 

February 4, 2023

Melissa & Piper

February 4, 2023

February 7, 2023

15th Birthday!

March 25, 2023

First Seizure Since Homeopathy

I had taken Piper out to potty and a seizure started. I ran her back into the office and held her upright not knowing how bad it would get.  She was alert throughout but, as you can see, terrified. 

March 25, 2023

March 26, 2023

GME No Longer In Remission

The next day at 11:08 am, Piper had a significantly worse seizure than the one the day before. 

We took her to the emergency room immediately after the seizure and spoke to her neurologist. 


Piper was started on high dose prednisone. GME was back. 

March 27, 2023

Prednisone Isn't Able To Control The Seizures

Over the next 24 hours, the seizures escalated very quickly in both intensity and length. 

Piper's prednisone dosage was increased 2x to the maximum and it was not able to stop the seizure activity.

We had to face the hard fact that there was nothing further medically that could be done to stop the GME progression. 

We were told the seizures would continue to get worse and longer.

We made the very hard decision to let her pass at home surrounded by her family and love.

March 27, 2023

March 28, 2023

It has been the honor of our lives to be Piper’s moms for the past 15 years and for us to be with Piper as she passed.

In 2007 I told Melissa I wanted a little dog to hang out with me, to follow me around, to play with me, and to be my best friend.

She found me Piper who came to live with us on April 13, 2008.

We very quickly discovered her intelligence was off the charts and I was in love.

I got so much more from Piper than I ever knew I needed.
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To our sweet little Piper,

Thank you for filling our hearts with so much love, laughter, and memories, and for making me a better human. I lived every day trying to be the person you thought I was.

You taught me so very much in your short time on this planet.

Trust. Empathy. Respectfulness. Loyalty. Love. Confidence. Courage.

Your battle with GME and being in remission for 6 years was a such a gift. We are forever grateful we had those extra 6 years.

Piper and AngelaYou were the bright spot in every minute of every day.

We don’t have words to describe how deeply we miss you.

I hope you and Tobie are playing flinch, harassing Elmo, teasing Henry, and playing king of the couch with Gracie.

I hope Terry is making you braid treats and you have a zillion games to play with. I hope you have a thousand soccer balls.

I hope you have as many blueberry treats as your little heart desires.

I hope you are at peace.

Thank you for your unconditional love, for following me around, for hanging out with me, for playing games with me, for being my best friend, and letting me be your Mom.

We love you and we miss you so very much.

- Your Heartbroken Moms, Angela & Melissa


Winnie the Pooh, “ How lucky I am to have something that makes saying goodbye so hard.”