Medication Tracker

When Piper was first diagnosed with GME, tracking all of the medications and their timings was overwhelming. 

We created a simple tracker that we used to verify the medication had been administered, and noted any side effects or how Piper was doing on the sheet. 

We would copy the current sheet, add the date into the first date under Sunday and the sheet auto-updates the rest of the date cells.

Facebook Support Groups

There are two Facebook Support Groups that we've found to be great places to ask questions and exchange information:

Reference Articles

We used a TON of information to pull together this site. Unfortunately, a lot of the scientific information is older and there are not a lot of good comprehensive review articles with up to date treatment regimes. We've noted a few that may be helpful to learn more.

For example, radiation therapy was found to not be highly beneficial except for possibly ocular GME. Your veterinary neurologist will use the protocol that has been shown to have the best results with minimal side effects. We urge you to find a veterinary neurologist with GME treatment experience.

Thank you to the amazing scientists and veterinarians who work so hard to help our GME warriors have quality of life. 

For those of you who want to take a deeper dive into the scientific journals, here are the reference materials: 

Adamo FP, O'Brien RT. Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs. Journal of the American Veterinary Medical Association. 2004;225:1211–1216. doi: 10.2460/javma.2004.225.1211.

Alley MR, Jones BR, Johnstone AC. Granulomatous meningoencephalomyelitis of dogs in New ZealandNew Zealand Veterinary Journal. 1983;31:117–119. doi: 10.1080/00480169.1983.34989.

Bailey CS, Higgins RJ. Characteristics of cerebrospinal fluid associated with canine granulomatous meningoencephalomyelitis: A retrospective studyJournal of the American Veterinary Medical Association. 1986;188:418–421.

Barber, R., & Koos, L. D. (2022). Treatment With Cytarabine at Initiation of Therapy With Cyclosporine and Glucocorticoids for Dogs With Meningoencephalomyelitis of Unknown Origin Is Not Associated With Improved Outcomes. Frontiers in Veterinary Science, 9, 925774. doi: 10.3389/fvets.2022.925774. PMID: 35754543; PMCID: PMC9226772.

Barber RM, Porter BF, Li Q, Greer KA, May M, Claiborne MK, Allison AB,
Howerth EW, Butler A, Wei S, Levine JM, Levine GJ, Brown DR, Schatzberg SJ. Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis. Journal of Veterinary Internal Medicine. 2012 Jul-Aug;26(4):962-8.

Benito Benito, M., Portero Fuentes, M., Manso-Diaz, G., Sánchez Madonado, B., & Pérez Diaz, C. (2022). Clinical signs, diagnostic imaging and histopathology in a dog with granulomatous meningoencephalitis manifested as a polyneuropathy. Vet Record Case Reports, 10(1), e324. doi: 10.1002/vrc2.324.

Great Easy To Read Article: Brooks, W. (2021). Granulomatous Meningoencephalitis (GME) in Dogs and Cats. Veterinary Partner. Retrieved from [URL]. Published: 07/18/2005. Original: 2005. Revised.

Brooks, W., DVM, DABVP. Prednisolone/Prednisone. Veterinary Partner. Published: 01/01/2001. Reviewed/Revised: 06/29/2021.

Coates, J. R., Barone, G., Dewey, C. W., Vitale, C. L., Holloway-Azene, N. M., & Sessions, J. K. (2007). Procarbazine as adjunctive therapy for treatment of dogs with presumptive antemortem diagnosis of granulomatous meningoencephalomyelitis: 21 cases (1998-2004). J Vet Intern Med, 21(1), 100-6. doi: 10.1892/0891-6640(2007)21[100:paatft];2.

Cuddon PA and Smith-Maxie L: 1984. Reticulosis of the central nervous system in the dog. Comp Cont Educ Pract Vet 6:23-32.

Eswaraka, J., Vemireddi, V., & Purdue, A. (2006). Granulomatous meningoencephalomyelitis (GME) in dogs: Winter Newsletter. ADDL Quarterly, Purdue University.

Kipar A, Baumgartner W, Vogl C, Gaedke K and Wellman M: 1998. Immunohistochemical characterization of inflammatory cells in brains of dogs with granulomatous encephalomyelitis. Vet Pathol 35: 43-52.

Munana K and Lutgen P: 1998. Prognostic factors for dogs with granulomatous meningoencephalomyelitis: 42 cases (1982-1996). JAVMA 212: 1902-1906. Ryan K, Marks SL and Kerwin SC: 2001. Granulomatous meningoencephalomyelitis in dogs. Compend Contin Educ Pract Vet 23(7): 644-650.

Nowak, K., Ratajczak–Wrona, W., Górska, M., Jabłońska, E. (2018). Parabens and their effects on the endocrine system. Molecular and Cellular Endocrinology, 474, 238-251.

Nuhsbaum MT, Powell CC, Gionfriddo JR, Cuddon PA. Treatment of granulomatous meningoencephalomyelitis in a dogVeterinary Ophthalmology. 2002;5:29–33. doi: 10.1046/j.1463-5224.2002.00215.x

Great Reference Article: O'Neill, E. J., Merrett, D., & Jones, B. (2005). Granulomatous meningoencephalomyelitis in dogs: A review. Irish Veterinary Journal, 58(2), 86–92. doi: 10.1186/2046-0481-58-2-86. PMID: 21851667; PMCID: PMC3113901. 

Schrauwen, I., Barber, R. M., Schatzberg, S. J., Siniard, A. L., Corneveaux, J. J., Porter, B. F., Vernau, K. M., Keesler, R. I., Matiasek, K., Flegel, T., Miller, A. D., Southard, T., Mariani, C. L., Johnson, G. C., & Huentelman, M. J. (2014). Identification of Novel Genetic Risk Loci in Maltese Dogs with Necrotizing Meningoencephalitis and Evidence of a Shared Genetic Risk across Toy Dog Breeds. PLOS ONE, 9(11), e112755. 

Song, J.-H., Yu, D.-H., Lee, H.-C., Hwang, T.-S., Kim, Y. J., An, S.-J., & Jung, D.-I. (2020). Evaluation of treatment with a combination of mycophenolate mofetil and prednisolone in dogs with meningoencephalomyelitis of unknown etiology: a retrospective study of 86 cases (2009–2017). BMC Vet Res, 16, 192. doi: 10.1186/s12917-020-02414-3. PMCID: PMC7291637. PMID: 32532259.

Thomas JB: 1998. Inflammatory diseases of the central nervous system in dogs. Clin Tech Small Anim Pract 13: 167. Wong CW and Sutton RH: 2002. Granulomatous meningoencephalomyelitis in dogs. Aust Vet Pract 32(1): 6-11.

Great Reference Article: Vitale, S., & Foss, K. (2019). Immune-Mediated Central Nervous System Disease—Current Knowledge and Recommendations. Top Companion Anim Med, 34, 22-29. doi: 10.1053/j.tcam.2018.11.003.

GME Research

Dr. Renee Barber and team at the University of Georgia College of Veterinary Medicine is one of the few that do research on GME, MUO, and other brain encephalitis diseases.

If you want to help fund her research, please visit this link:

Thank You!

Thank you to everyone who gave feedback and input on this resource website!

Thank you to pet parents who have batled MUE or GME alongside their furry family. YOU ARE AMAZING!

Thank you for sharing your experiences and your stories and letting us incorporate them into the website.

Thank you to Piper for letting us be her humans. We lived every day trying to be the people you thought we were! We love you forever and always!